The Clouser Minnow may be the single most effective fly for more species of fish that has ever been tied.
You can fish them deep, fast, slow, and they work for almost any species that you can throw and fly at. Definitely a great fly for any anlgers box, we always have some on hand in the salt, it's the just in case pattern, if a jack swims by, you need to sink deeper into the channel, or you run out of bonefish flies and you need something that just catches fish. In fresh water they catch crappies and carp to striper and pike.
We carry the Clouser Minnow here in sizes 2 and 6 in Chartreuse/white, gray/white, Olive/white, chartreuse/yellow, and Sculpin.